YM-170320, a novel lipopeptide antibiotic inducing morphological change of colonies in a mutant of Candida tropicalis pK233.

colonies was white to gray, and the reverse was colored pale yellowish brown. The strain produced no reproductive structures even on sterilized natural substrates. The absence of morphological characteristics implied that this fungus could be treated as a deuteromycete in the Agonomycetes3). YM-170320 (1) was produced by solid state fermentation. Vegetative mycelia of strain YL-03706F growing on potato-dextrose agar were used to prepare the fermentation inoculum in a 500-ml Erlenmeyer flask containing 100ml of a seed medium consisting of glucose 1%, potato starch 2%, yeast extract 0.5%, Polypepton (Nihon Pharmaceutical Co., Ltd.) 0.5% and CaCO3